Professor Seppo Ylä-Herttuala formed the company back in 1993. FinVector was originally named Ark Therapeutics before undergoing a name change to FinVector Vision Therapies in 2013 and later to FinVector in 2018.
We offer services across a wide range of viral-based product types, including Adenoviral, AAV, and Lentiviral-based vectors. From our cutting-edge fully-licensed GMP manufacturing facility in Finland, we have built an extensive pipeline of gene therapy products and technologies for our clients.
Adenoviral vectors are the most frequently used vectors in gene therapy clinical trials. Adenoviruses have proven an efficient tool for the treatment of many type of diseases, such as cancer, vascular disease and monogenic disorders. The most commonly used adenovirus serotypes in gene therapy are 2 (Ad2) and 5 (Ad5). Adenoviruses infect both dividing and quiescent cells having broad tropism and transient transgene expression. The viral particles are rather stable and easy to manipulate. In addition, adenoviral vectors can be produced in high titters.
Lentiviruses have valuable capabilities as vectors in gene therapy. This is because they have low immunogenicity and transduce both dividing and non-dividing cells with high efficiency, achieve long-term stable expression of the transgene. This gives lentiviruses a wide range of potential therapeutic applications. However, the generation of clinical grade vectors in quantities large enough for therapeutic use is still challenging and often limiting for preclinical and clinical development projects. To solve this unmet need, FinVector has established and patented a practical means of manufacturing lentiviral vectors in suspension cells using baculovirus constructs to supply the genetic components.
The non-lytic adeno-associated virus (AAV) has evolved into a gene therapy tool of considerable importance since it has been used in a wide range of gene therapy approaches. AAV has a broad host and cell type tropism and it transduces both dividing and non-dividing cells. So far AAV vectors has been manufactured for preclinical studies. FinVector has several areas that are dedicated for viral vector process development suitable for upstream and downstream work and several campaign based cGMP facilities.
FinVector is unique, having own proprietary platform for Adenovirus and Lentivirus-based products for production in adherent or suspension culture. We have established a scalable serum-free suspension culture-based manufacturing process platform for adenoviruses (ATOSUS) that has been seen by regulatory authorities and used for clinical supply. In addition, we have a scalable AAV Adherent based iCELLIs platform and a serum-free suspension-based platform for production of lentiviruses. We are currently validating our commercial scale process, and we continue to develop our own products. The team at FinVector is passionate about delivering excellence for our clients, and we look forward to working with new and existing partners in the years to come.
The manufacture is supported by QA supervision and QC control of materials and products and an in-house QP for clinical and commercial release. These manufacturing capabilities are purpose-built alongside FinVector's research and development laboratories. FinVector offers qualified person release of drug products . We work closely with qualified couriers for cold chain distribution, and together we can transport your drug product to your facility or directly to your distribution or clinical site. We also have expertise in Pharmacy Manual preparation especially for the handling of gene-therapy products in pharmacies within Europe.
FinVector works with a range of clients from Large Pharma to spin out Biotech companies providing our expertise to develop and/or clinical manufacture tomorrows next generation Gene Therapy products.
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